Role of Ghrelin in Streptozotocin-Induced Diabetic Hyperphagia
نویسندگان
چکیده
منابع مشابه
Relation between Plasma Levels of Ghrelin and Hyperphagia in Streptozotocin-Induced Diabetes in Male Albino Rats
Background: Ghrelin, a hormone identified in the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) and the peripheral or central administration of ghrelin increases food intake and body weight. Ghrelin release and gene expression are regulated by nutrient flux, such that plasma ghrelin levels increase steadily before meal onset and fall rapidly after food ing...
متن کاملLeptin downregulates ghrelin levels in streptozotocin-induced diabetic mice.
Ghrelin, an orexigenic peptide produced in the stomach, is increased in streptozotocin (STZ)-induced diabetic (DM) mice. This study clarifies the regulation of ghrelin levels by leptin in STZ-DM mice. STZ-DM mice had higher plasma ghrelin concentrations and greater ghrelin mRNA expression than control mice. Changes in ghrelin levels were dose dependently attenuated by the subcutaneous injection...
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Ghrelin, an orexigenic peptide produced in the stomach has shown to elicit peripheral actions including regulation of pancreatic β-cell function. The aim of the study is to clarify the regulation of plasma ghrelin concentrations by insulin in streptozotocin (STZ) induced diabetic rats. Adult male Wistar rats were divided into control and three experimental groups as each group had 7 rats (n=28)...
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Background: Hypertension is considered an independent risk factor for cardiovascular mortality in diabetic patients. The present study was designed to determine the role of gamma amino butyric acid B (GABAB) receptor and L-arginine (L-Arg) in GABA-induced vasorelaxation in normal and streptozotocin-induced diabetic rat vessels. Methods: Diabetes was induced by a single i.p. injection of strepto...
متن کاملThe Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy
OBJECTIVE Diabetic nephropathy is one of the major causes of renal failure, which is accompanied by the production of reactive oxygen species (ROS). Nrf2 is the primary transcription factor that controls the antioxidant response essential for maintaining cellular redox homeostasis. Here, we report our findings demonstrating a protective role of Nrf2 against diabetic nephropathy. RESEARCH DESI...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2002
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2002-220612